One of the persistent challenges of the Pharmaceutical industry has been maintaining the safety and efficacy of drug products in patients over time. Enhanced Pharmaceuticals (EP) has discovered specific ways to modulates the targeted receptor response,…

There are at least three companies including Enhanced Pharmaceuticals (Inverseon and Pain Therapeutics (PTIE) being the other two) that were formed around similar empirical findings that agonist/antagonist combinations are better than the agonist alone, but general pharmacological science has been rather slow to follow up on these experimental studies. Perhaps because it is an unexpected result that differs from most pharmacological theories and clinical intuition, it hasn’t caught on in the last 16 years since the filing of my first patent on September 30, 1992. This puzzles me, because these findings represent a paradigm shift in the field toward discovering and making safer and more effective drugs.

With regard to your comments about the ethical dilemma faced by big pharma selling less pills if they are more effective, I don’t believe that to be the case.
Instead, I see big pharma as looking in all the wrong places to extend their patent franchises while ignoring or remaining unaware of technologies such as ours to improve their drugs.

As you mentioned in your question concerning such combinations, there remains more experimental work to do, but I can tell you that from our initial studies it appears that these combinations work well in animals that desensitize differently and that they appear to work after desensitizing a targeted receptor system such as the Guinea-pig trachea (an accepted experimental system for asthma studies). In our animal studies, there were also less cardiac arrhythmias with our drug combinations than with the agonist (activating) drugs alone. These studies are promising, but need further research. Because our work holds such promise for better asthma, heart failure and Parkinson drugs, we continue to hope that investors will see our potential and rise to the opportunities.

Thank you again for your thoughtful and well written analysis!